Treatment outcomes in patients with multidrug‐resistant tuberculosis in north‐west Ethiopia
Alene, Kefyalew Addis, Viney, Kerri, McBryde, Emma S., Tsegaye, Adino Tesfahun , and Clements, Archie C.A. (2017) Treatment outcomes in patients with multidrug‐resistant tuberculosis in north‐west Ethiopia. Tropical Medicine and International Health , 22 (3). pp. 351-362.
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Abstract
Objective: Multidrug-resistant tuberculosis (MDR-TB) is an emerging public health problem in Ethiopia. The aim of this study was to assess MDR-TB treatment outcomes and determine predictors of poor treatment outcomes in north-west Ethiopia.
Mehtods: A retrospective cohort study was conducted using all MDR-TB patients who were enrolled at Gondar University Hospital since the establishment of the MDR-TB programme in 2010. A Cox proportional hazard model was used to identify the predictors of time to poor treatment outcomes, which were defined as death or treatment failure.
Results: Of the 242 patients who had complete records, 131 (54%) were cured, 23 (9%) completed treatment, 31 (13%) died, four (2%) experienced treatment failure, 27 (11%) were lost to follow-up, six (2%) transferred out, and 20 (8%) were still on treatment at the time of analysis. The overall cumulative probability survival of the patients at the end of treatment (which was 24 months in duration) was 80% (95% CI: 70%, 87%). The proportion of patients with poor treatment outcomes increased over time from 6% per person-year (PY) during 2010-2012, to 12% per PY during 2013-2015. The independent predictors of time to poor treatment outcome were being anaemic [AHR = 4.2; 95% CI: 1.1, 15.9] and being a farmer [AHR = 2.2; 95% CI: 1.0, 4.9].
Conclusions: Overall, in north-west Ethiopia, the MDR-TB treatment success rate was high. However, poor treatment outcomes have gradually increased since 2012. Being a farmer and being anaemic were associated with poor treatment outcomes. It would be beneficial to assess other risk factors that might affect treatment outcomes such as co-infection with malaria, poverty and other socio-economic and biological risk factors.
Item ID: | 47379 |
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Item Type: | Article (Research - C1) |
ISSN: | 1365-3156 |
Keywords: | Ethiopia; multidrug-resistant tuberculosis; outcomes; tuberculosis |
Date Deposited: | 07 Mar 2017 01:40 |
FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 50% 44 HUMAN SOCIETY > 4407 Policy and administration > 440706 Health policy @ 50% |
SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50% 92 HEALTH > 9202 Health and Support Services > 920207 Health Policy Evaluation @ 50% |
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