Assessment and validation of a novel angiographic scoring system for peripheral artery disease

Morris, D.R., Singh, T.P., Moxon, J.V., Smith, A., Stewart, F., Jones, R.E., and Golledge, J. (2017) Assessment and validation of a novel angiographic scoring system for peripheral artery disease. British Journal of Surgery, 104. pp. 544-554.

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Abstract

Background: Angiography is used routinely in the assessment of lower-limb arteries, but there are few well validated angiographic scoring systems. The aim of this study was to develop and validate a novel angiographic scoring system for peripheral artery disease.

Methods: An angiographic scoring system (the ANGIO score) was developed and applied to a sample of patients from a single vascular surgical department who underwent CT angiography of the lower limbs. The reproducibility of the ANGIO score was compared with those of the Bollinger and Trans-Atlantic inter-Society Consensus (TASC) IIb systems in a series of randomly selected patients. Associations between the ANGIO score and lower-limb ischaemia, as measured by the ankle : brachial pressure index (ABPI), and outcome events (major lower-limb amputations and cardiovascular events – myocardial infarction, stroke and cardiovascular death) were assessed.

Results: Some 256 patients undergoing CT angiography were included. The interobserver reproducibility of the ANGIO score was better than that of the other scoring systems examined (κ = 0·90, P = 0·002). There was a negative correlation between the ANGIO score and ABPI (ρ = −0·33, P = 0·008). A higher ANGIO score was associated with an increased risk of major lower-limb amputation (hazard ratio (HR) for highest versus lowest tertile 9·30, 95 per cent c.i. 1·95 to 44·38; P = 0·005) and cardiovascular events (HR 2·73, 1·31 to 5·70; P = 0·007) following adjustment for established risk factors.

Conclusion: The ANGIO score provided a reproducible and valid assessment of the severity of lower-limb ischaemia and risk of major amputation and cardiovascular events in these patients with peripheral artery disease.

Item ID: 47299
Item Type: Article (Refereed Research - C1)
ISSN: 1365-2168
Funders: National Health and Medical Research Council of Australia (NHMRC), Queensland Government, Townsville Hospital Private Practice Trust Fund (THPPTF), Office of Health and Medical Research, Queensland Government
Projects and Grants: NHMRC #1063476, 1000967 & 1019921
Date Deposited: 15 Feb 2017 05:04
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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