EAACI molecular allergology user's guide

Matricardi, P.M., Kleine-Tebbe, J., Hoffmann, H.J., Valenta, R., Hilger, C., Hofmaier, S., Aalberse, R.C., Agache, I., Asero, R., Ballmer-Weber, B., Barber, D., Beyer, K., Biedermann, T., Bilò, M.B., Blank, S., Bohle, B., Bosshard, P.P., Breiteneder, H., Brough, H.A., Caraballo, L., Caubet, J.C., Crameri, R., Davies, J.M., Douladiris, N., Ebisawa, M., Elgenmann, P.A., Fernandez-Rivas, M., Ferreira, F., Gadermaier, G., Glatz, M., Hamilton, R.G., Hawranek, T., Hellings, P., Hoffmann-Sommergruber, K., Jakob, T., Jappe, U., Jutel, M., Kamath, S.D., Knol, E.F., Korosec, P., Kuehn, A., Lack, G., Lopata, A.L., Mäkelä, M., Morisset, M., Niederberger, V., Nowak-Wezgrzyn, A.H., Papadopoulos, N.G., Pastorello, E.A., Pauli, G., Platts-Mills, T., Posa, D., Poulsen, L.K., Raulf, M., Sastre, J., Scala, E., Schmid, J.M., Schmid-Grendelmeier, P., van Hage, M., van Ree, R., Vieths, S., Weber, R., Wickman, M., Muraro, A., and Ollert, M. (2016) EAACI molecular allergology user's guide. Pediatric Allergy and Immunology, 27 (S23). pp. 1-250.

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Abstract

The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from primary sensitization. Part B discusses clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, molds, mites, animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food allergy, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.

Item ID: 47090
Item Type: Article (Research - C1)
ISSN: 1399-3038
Keywords: allergy diagnosis, component-resolved diagnosis, IgE cross-reactivity, panallergens, non-specific lipid transfer proteins, pathogenesis-related protein family 10, polcalcins, profilins, tropomyosins, parvalbumins, serum albumins, allergy, anaphylaxis, asthma, atopic dermatitis, component-resolved diagnosis, diagnosis, diagnostic algorithms, food allergy, guidelines, IgE, lipocalins, microarray, molecular allergology, non-specific lipid transfer proteins, panallergens, pathogenesis-related protein family 10, polcalcins, profilins, precision medicine, parvalbumins, serum albumins
Additional Information:

Special Issue: EAACI Molecular Allergology User's Guide, Berlin, 16-18 April 2015.

Date Deposited: 18 Jan 2017 07:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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