Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013

Rith, Sareth, Davis, C. Todd, Duong, Veasna, Sar, Borann, Horm, Srey Viseth, Chin, Savuth, Ly, Sovann, Laurent, Denis, Richner, Beat, Oboho, Ikwo, Jang, Yunho, Davis, William, Thor, Sharmi, Balish, Amanda, Iuliano, A. Danielle, Sorn, San, Holl, Davun, Sok, Touch, Seng, Heng Seng, Tarantola, Arnaud, Tsuyuoka, Reiko, Parry, Amy, Chea, Nora, Allal, Lotfi, Kitsutani, Paul, Warren, Dora, Prouty, Michael, Horwood, Paul, Widdowson, Marc-Alain, Lindstrom, Stephen, Villanueva, Julie, Donis, Ruben, Cox, Nancy, and Buchy, Phillipe (2014) Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013. Journal of Virology, 88 (23). pp. 13897-13909.

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Abstract

Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.

Item ID: 46972
Item Type: Article (Research - C1)
ISSN: 1098-5514
Funders: World Health Organization, Food and Agriculture Organization in Cambodia (FAOC), Office of the Assistant Secretary for Preparedness and Response, USA, U.S. Department of Health and Human Services
Date Deposited: 01 Feb 2017 03:56
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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