Seroepidemiology of human enterovirus 71 infection among children, Cambodia

Horwood, Paul F., Andronico, Alessio, Tarantola, Arnaud, Salje, Henrik, Duong, Veasna, Mey, Channa, Ly, Sovann, Dussart, Philippe, Cauchemez, Simon, and Buchy, Philippe (2016) Seroepidemiology of human enterovirus 71 infection among children, Cambodia. Emerging Infectious Diseases, 22 (1). pp. 92-95.

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Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak. We used serum samples collected during 2000–2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

In the Asia-Pacific region, human enterovirus 71 (EV71) is a widespread pathogen that causes hand, foot and mouth disease among children. Potentially fatal neurologic and systemic manifestations develop in a small proportion of patients (1).

In Cambodia during 2012, a disease outbreak characterized by severe encephalitis with cardiovascular collapse and pulmonary edema seized international headlines and resulted in the death of at least 54 children; EV71 subgenogroup C4 was identified as the cause (2). The large number of deaths during a short period was a concern for health authorities. To investigate whether EV71 had circulated in Cambodia before the 2012 outbreak, we retrospectively screened blood samples collected from children during 2000–2011.

Item ID: 46933
Item Type: Article (Research - C1)
ISSN: 1080-6059
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Funders: Ministry of Health of the Kingdom of Cambodia (MHKC), Asian Development Bank (ADB)
Projects and Grants: MHKC Second Health Sector Support Program
Date Deposited: 26 Jan 2017 22:13
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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