Proteinuria during dengue fever in children

Andries, Anne-Claire, Duong, Veasna, Cappelle, Julien, Ong, Sivuth, Kerleguer, Alexandra, Ly, Sowath, Tarantola, Arnaud, Horwood, Paul F., Sakuntabhai, Anavaj, Dussart, Philippe, and Buchy, Philippe (2017) Proteinuria during dengue fever in children. International Journal of Infectious Diseases, 55. pp. 38-44.

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Abstract

Objectives: This study aimed to investigate proteinuria occurring during dengue disease in children and assess if measurement of this parameter can help physicians in the clinical management of patients.

Methods: Proteinuria was assessed by dipstick and quantified by urine protein:creatinine ratio (UPCR) in samples from patients hospitalized with a confirmed dengue infection and in healthy controls.

Results: The dipstick tested positive in 42.9% of the patients presenting at hospital with dengue versus 20.0% in healthy controls. UPCR increased during the critical phase of the disease; peaking one week after fever onset then decreasing as the patients recovered. Patients with warnings signs or severe dengue were more likely to present with proteinuria detected by UPCR at the time of hospital admission compared to patients without warning signs. The sensitivity of this marker, however, was limited as only 16.1% of the patients with warning signs had proteinuria.

Conclusions: Urine dipstick and UPCR do not seem to be very valuable for the triage of the patients at the time of the initial consultation but the observation of a decrease of the UPCR during the course of the illness appears to indicate an evolution towards recovery.

Item ID: 46919
Item Type: Article (Research - C1)
ISSN: 1878-3511
Keywords: Dengue; proteinuria; urine; dipstick; UPCR; urine electrophoresis
Additional Information:

© 2017 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Funders: European Union Seventh Framework Programme (EU FP7)
Projects and Grants: EU FP7 Grant Agreement no. 282 378
Date Deposited: 25 Jan 2017 01:53
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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