Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice
Martinez, Nuria, Ketheesan, Natkunam, Martens, Gregory W., West, Kim, Lien, Egil, and Kornfeld, Hardy (2016) Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice. Microbes and Infection, 18 (10). pp. 649-655.
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Abstract
Diabetes is associated with increased susceptibility to Klebsiella pneumoniae and poor prognosis with infection. We demonstrate accelerated mortality in mice with streptozotocin-induced diabetes following tracheal instillation of K. pneumoniae. Diabetic mice recruited fewer granulocytes to the alveolar airspace and had reduced early production of CXCL1, CXCL2, IL-1 beta and TNF-alpha following tracheal instillation of K. pneumoniae-lipopolysaccharide. Additionally, TLR2 and TIRAP expression following K. pneumoniae-lipopolysaccharide exposure was decreased in hyperglycemic mice. These findings indicate that impaired innate sensing and failure to rapidly recruit granulocytes to the site of infection is a mechanism for diabetic susceptibility to respiratory K. pneumoniae infection.
| Item ID: | 46518 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1769-714X |
| Keywords: | diabetes, Klebsiella pneumoniae, lung, pneumonia |
| Funders: | National Institutes of Health (NIH), USA, Research Council of Norway |
| Projects and Grants: | NIH grant HL081149, NIH grant AI057588 |
| Date Deposited: | 23 Nov 2016 07:35 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320220 Pathology (excl. oral pathology) @ 100% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 20% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920115 Respiratory System and Diseases (incl. Asthma) @ 80% |
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