Molecular cross-talk between the liver and white adipose tissue links excessive noURIshment to hepatocellular carcinoma

Roberts, Alexandra A., and Hebbard, Lionel W. (2016) Molecular cross-talk between the liver and white adipose tissue links excessive noURIshment to hepatocellular carcinoma. Translational Cancer Research, 5 (Supplement 6). S1222-S1226.

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Abstract

In their recent study published in Cancer Cell, Gomes and colleagues uncovered a novel mechanism driving obesity-triggered hepatocellular carcinoma (HCC). The authors revealed a feed-forward loop between hepatic unconventional prefoldin RPB5 interactor (URI) and cytokine interleukin-17A (IL-17A), and showed that chronically high expression of both proteins induces DNA damage, followed by systemic inflammation, which initiates non-alcoholic steatohepatitis (NASH) and HCC. URI and IL-17A are involved in cross-talk between the liver and white adipose tissue (WAT), with lipolysis, neutrophil infiltration and insulin resistance occurring in WAT, resulting in hepatosteatosis, injury and HCC in the liver. These results suggest that targeting URI and IL-17 levels may be a useful therapeutic strategy in the treatment of obesity-driven HCC.

Item ID: 46497
Item Type: Article (Commentary)
ISSN: 2219-6803
Keywords: hepatocellular carcinoma (HCC); non-alcoholic steatohepatitis (NASH); obesity; liver cancer
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Funders: James Cook University (JCU), Cancer Council of New South Wales (CC)
Projects and Grants: JCU Rising Star Grant, CC Project grant APP1069733, JCU Development Grant
Date Deposited: 02 Dec 2016 03:03
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111203 Cancer Genetics @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111201 Cancer Cell Biology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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