Schistosomiasis vaccines: where do we stand?

Tebeje, Biniam Mathewos, Harvie, Marina, You, Hong, Loukas, Alex, and McManus, Donald P. (2016) Schistosomiasis vaccines: where do we stand? Parasites & Vectors, 9. 528. pp. 1-15.

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Abstract

Schistosomiasis, caused mainly by S. mansoni, S. haematobium and S. japonicum, continues to be a serious tropical disease and public health problem resulting in an unacceptably high level of morbidity in countries where it is endemic. Praziquantel, the only drug currently available for treatment, is unable to kill developing schistosomes, it does not prevent re-infection and its continued extensive use may result in the future emergence of drug-resistant parasites. This scenario provides impetus for the development and deployment of anti-schistosome vaccines to be used as part of an integrated approach for the prevention, control and eventual elimination of schistosomiasis. This review considers the present status of candidate vaccines for schistosomiasis, and provides some insight on future vaccine discovery and design.

Item ID: 46401
Item Type: Article (Research - C1)
ISSN: 1756-3305
Keywords: Schistosoma mansoni, Schistosoma haematobium, Schistosoma japonicum, Immune response, Schistosomiasis, Vaccine, Immune protection, Antigen discovery
Date Deposited: 09 Nov 2016 07:50
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%
SEO Codes: 92 HEALTH > 9202 Health and Support Services > 920204 Evaluation of Health Outcomes @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 50%
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