Effect of partially protected butyrate used as feed additive on growth and intestinal metabolism in sea bream (Sparus aurata)

Robles, R., Lozano, A.B., Sevilla, A., Marquez, L., Nuez-Ortín, W., and Moyano, F.J. (2013) Effect of partially protected butyrate used as feed additive on growth and intestinal metabolism in sea bream (Sparus aurata). Fish Physiology and Biochemistry, 39 (6). pp. 1567-1580.

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Abstract

Butyrate is a short-chain fatty acid extensively used in animal nutrition since it promotes increases in body weight and other multiple beneficial effects on the intestinal tract. Although such effects have been demonstrated in several species, very few studies have assessed them in fish. On the other hand, little is known about the metabolic processes underlying these effects. In the present work, growth parameters and changes in more than 80 intestinal metabolites (nucleotides, amino acids and derivatives, glycolytic intermediates, redox coenzymes and lipid metabolism coenzymes) have been quantified in juvenile sea bream fed a butyrate-supplemented diet. Results showed a significant increase in the weight of fish receiving butyrate, while metabolomics provided some clues on the suggested effects of this feed additive. It seems that butyrate increased the availability of several essential amino acids and nucleotide derivatives. Also, the energy provision for enteric cells might have been enhanced by a decrease in glucose and amino acid oxidation related to the use of butyrate as fuel. Additionally, butyrate might have increased transmethylation activity. This work represents an advance in the knowledge of the metabolic consequences of using butyrate as an additive in fish diets.

Item ID: 45979
Item Type: Article (Research - C1)
ISSN: 1573-5168
Keywords: butyrate, Sea bream, metabolomics, amino acids, growth
Funders: Consejería de Innovación, Junta de Andlucía (CI)
Projects and Grants: CI project P09-AGR-5234, CI project BIO2011-29233-C02-01, CI project MCINN/FEDER-EU
Date Deposited: 10 Oct 2016 03:02
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110199 Medical Biochemistry and Metabolomics not elsewhere classified @ 100%
SEO Codes: 83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8301 Fisheries - Aquaculture > 830199 Fisheries - Aquaculture not elsewhere classified @ 100%
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