Pharmacotherapy of conduct disorder: challenges, options and future directions

Hambly , Jessica L., Khan, Sohil, McDermott, Brett, Bor, William, and Haywood, Alison (2016) Pharmacotherapy of conduct disorder: challenges, options and future directions. Journal of Psychopharmacology, 30 (10). pp. 967-975.

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There is a critical need for evaluation of the pharmacotherapies used in conduct disorder (CD), due to the high incidence of off-label prescribing. The aim of this review was to identify concerns associated with the safety, efficacy and impact on quality of life (QOL) that pharmacotherapy has in children and adolescents with CD. A systematic review was undertaken using pre-defined search criteria and four databases, including reference searches. We assessed these studies using the Strength of Recommendation Taxonomy, Grading of Recommendations Assessment, Development and Evaluation, and Review Manager Risk of Bias (RevMan®) tools. There were 12 randomised controlled trials that met our inclusion criteria. Studies included: antipsychotics, atomoxetine, lithium, clonidine, divalproex sodium and psychostimulants. The antipsychotics demonstrated efficacy, but were associated with adverse effects. Other agents demonstrated mixed responses, highlighting the lack of clinical significance and increased incidence of adverse effects. The management of related adverse effects was addressed to assist with clinical gaps. Overall, there is limited evidence regarding the role of pharmacotherapy in CD. More research is needed that takes into account the heterogeneity of CD and analysis of pharmacotherapy in pure CD.

Item ID: 45888
Item Type: Article (Research - C1)
ISSN: 1461-7285
Keywords: adverse effects, children, conduct disorder, drugs, efficacy, pharmacotherapy, quality of life, review, safety, young patients, youth
Funders: Griffith University (GU)
Projects and Grants: GU Australian Postgraduate Award
Date Deposited: 29 Sep 2016 05:09
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321403 Clinical pharmacy and pharmacy practice @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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