Role of catecholamine levels and quality-of-life domains in patients with oral neoplasms

Xie, Huixu, Li, Bo, He, Yan, Li, Longjiang, and Ye, Qingsong (2016) Role of catecholamine levels and quality-of-life domains in patients with oral neoplasms. International Journal of Clinical and Experimental Medicine, 9 (3). pp. 6765-6770.

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Abstract

Background: Oral cancer has a profound impact on quality of life, but the relationship between quality of life and tumorigenesis, catecholamine levels, and disease stage in oral cancer patients is not well understood.

Methods: Pre-surgical quality of life was determined using the Short Form 36 (SF-36) health-related quality of life questionnaire in 75 oral neoplasm patients, including 40 oral carcinoma patients and 35 benign oral tumor patients. The plasma epinephrine and norepinephrine concentrations were assessed using high performance liquid chromatography-mass spectrometry-mass spectrometry, and data were analyzed using multivariate logistic regression models.

Results: There were significant differences in pain, general health, and mental health SF-36 subscores between the oral carcinoma and benign oral tumor groups. Multivariate logistic regression models showed that the SF-36 scores in the oral carcinoma group were significantly lower than those in the benign oral tumor group.

Conclusions: These findings show that general health is affected in oral neoplasm patients and stress hormones can affect quality of life in oral carcinoma patients; furthermore, plasma catecholamines and mental health contribute to the progression of oral carcinoma.

Item ID: 45518
Item Type: Article (Research - C1)
ISSN: 1940-5901
Keywords: oral neoplasm, catecholamine, mental health, logistic regression models, SF-36, quality of life
Funders: Sichuan University (SU)
Projects and Grants: SU Initial Scientific Research Fund of Young Teachers in West China Hospital of Stomatology
Date Deposited: 13 Jul 2016 07:34
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111299 Oncology and Carcinogenesis not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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