Zika virus infection, associated microcephaly, and low yellow fever vaccination coverage in Brazil: is there any causal link?

de Góes Cavalcanti, Luciano Pamplona, Tauil, Pedro Luiz, Alencar, Carlos Henrique, Oliveira, Wanderson, Teixeira, Mauro Martins, and Heukelbach, Jorg (2016) Zika virus infection, associated microcephaly, and low yellow fever vaccination coverage in Brazil: is there any causal link? Journal of Infection in Developing Countries, 10 (6). pp. 563-566.

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Introduction: Since the end of 2014, Zika virus (ZIKV) infection has been rapidly spreading in Brazil.

Methodology: To analyze the possible association of yellow fever vaccine with a protective effect against ZIKV-related microcephaly, the following spatial analyses were performed, using Brazilian municipalities as units: i) yellow fever vaccination coverage in Brazilian municipalities in individuals aged 15-49; ii) reported cases of microcephaly by municipality; and iii) confirmed cases of microcephaly related to ZIKV, by municipality. SaTScan software was used to identify clusters of municipalities for high risk of microcephaly.

Results: There were seven significant high risk clusters of confirmed microcephaly cases, with four of them located in the Northeast where yellow fever vaccination rates were the lowest. The clusters harbored only 2.9% of the total population of Brazil, but 15.2% of confirmed cases of microcephaly.

Conclusion: We hypothesize that pregnant women in regions with high yellow fever vaccination coverage may pose their offspring to lower risk for development of microcephaly. There is an urgent need for systematic studies to confirm the possible link between low yellow fever vaccination coverage, Zika virus infection and microcephaly.

Item ID: 45488
Item Type: Article (Research - C1)
ISSN: 1972-2680
Keywords: Zika, Brazil, epidemiology
Additional Information:

Copyright © 2016 de Góes Cavalcanti et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Date Deposited: 10 Aug 2016 07:35
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320705 Medical virology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 50%
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