Miles, John J., Silins, Sharon L., Brooks, Andrew G., Davis, Joanne E., Misko, Ihor, and Burrows, Scott R. (2005) T-cell grit: large clonal expansions of virus-specific CD8⁺ T cells can dominate in the peripheral circulation for at least 18 years. Blood, 106 (13). pp. 4412-4413.

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Abstract

[Extract] Epstein-Barr virus (EBV) establishes a latent, life-long infection in more than 95% of the human adult population. Antigen-specific, cytolytic T lymphocytes (CTLs) are thought to be of central importance in controlling EBV in both primary and latent infection states. While a good deal is known about the CTL dynamics during primary infection and convalescence, little is known about the CTL repertoire during the decades of infection after first contact. For example, do CTL clones persist indefinitely throughout an individual's lifetime or do new naive T-cell expansions emerge to help refresh the repertoire? We addressed this question by investigating the CTL dynamics toward immunodominant EBV epitopes up to 18 years apart, which is, to our knowledge, the longest follow-up study of T-cell responses conducted in humans.

Item ID:	45410
Item Type:	Article (Editorial)
ISSN:	1528-0020
Date Deposited:	07 Sep 2016 04:58
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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