Brennan, Rebekah M., Miles, John J., Silins, Sharon L., Bell, Melissa J., Burrows, Jacqueline M., and Burrows, Scott R. (2007) Predictable αβ T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope. Journal of Virology, 81 (13). pp. 7269-7273.

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Abstract

Human cytomegalovirus (HCMV) elicits a very large burden on the immune system, with approximately one in ten T cells being reserved solely to manage this infection. However, information on the clonotypic composition of these vast T-cell populations is limited. In this study, we sequenced 116 T-cell receptor (TcR) αβ-chains specific for the highly immunogenic HLA-B*3501-resticted epitope IPSINVHHY from the pp65 antigen. Interestingly, T cells recovered from all donors bore an identical or near-identical TRBV28/TRBJ1-4/TRAV17/TRAJ33 TcR. The ability to predict the responding αβ TcR repertoire before viral infection should prove a powerful tool for basic and clinical immunology.

Item ID:	45394
Item Type:	Article (Research - C1)
ISSN:	1098-5514
Date Deposited:	06 Sep 2016 04:01
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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