Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition
Burrows, Jacqueline M., Bell, Melissa J., Brennan, Rebekah, Miles, John J., Khanna, Rajiv, and Burrows, Scott R. (2008) Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition. Molecular Immunology, 45 (6). pp. 1818-1824.
![[img]](https://researchonline.jcu.edu.au/style/images/fileicons/application_pdf.png) |
PDF (Published Version)
- Published Version
Restricted to Repository staff only |
Abstract
A classic feature of antigen presentation for CD8⁺ T cell recognition is that MHC class I molecules generally present peptides of 8-10 amino acids in length. However, recent studies have demonstrated that peptides of >10 residues play a significant role in immune surveillance by T cells restricted by some HLA class I alleles. In the present study, we describe several examples of unusually long viral peptides of 11 or 12 residues, recognized by CTLs in the context of HLA-B35. Interestingly, all these immunogenic peptides completely encompass shorter canonical length sequences that conform to the HLA-B35 binding motif, but which fail to stimulate detectable T cell responses. The mechanism for this phenomenon appears to involve the preferential binding to HLA-B35 of the atypically long CD8⁺ T cell target peptides over the overlapping canonical length sequences. These data suggest that the peptide length specificity of some HLA class I alleles is broad, allowing peptides of >10 residues to sometimes dominate over canonical length class I ligands as targets for T cell recognition.
| Item ID: | 45393 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1872-9142 |
| Keywords: | human; CTL; viral; MHC class I; antigen presentation/processing |
| Funders: | National Health and Medical Research Council of Australia (NHMRC) |
| Date Deposited: | 07 Sep 2016 01:44 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100% |
| Downloads: |
Total: 6 |
| More Statistics |
Actions (Repository Staff Only)
 |
Item Control Page |