Bell, Melissa J., Brennan, Rebekah, Miles, John J., Moss, Denis J., Burrows, Jacqueline M., and Burrows, Scott R. (2008) Widespread sequence variation in Epstein‐Barr virus nuclear antigen 1 influences the antiviral T cell response. Journal of Infectious Diseases, 197 (11). pp. 1594-1597.

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Abstract

Epstein-Barr virus (EBV) nuclear antigen (EBNA) 1 is perhaps the most widely studied EBV protein, because of its critical role in maintaining the EBV episome and its expression in all EBV-associated malignancies. Much of this research has focused exclusively on the EBV wild-type (wt) strain (B95-8). Sequence analysis of the gene encoding for EBNA1 in EBV isolates from 43 Caucasians has now revealed considerable EBNA1 sequence divergence from the EBV wt strain in the majority of isolates from this population group. Importantly, T cell recognition of an endogenously processed HLA-B8 - binding EBNA1 epitope was greatly influenced by this sequence polymorphism.

Item ID:	45390
Item Type:	Article (Research - C1)
ISSN:	1537-6613
Funders:	National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants:	NHMRC grant 389830, NHMRC grant 442902, NHMRC grant 442928
Date Deposited:	06 Sep 2016 23:35
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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