Effects of moderate and substantial hypoxia on erythropoietin levels in rainbow trout kidney and spleen

Lai, Jimmy C.C., Kakuta, Izuru, Mok, Helen O.L., Rummer, Jodie L., and Randall, David (2006) Effects of moderate and substantial hypoxia on erythropoietin levels in rainbow trout kidney and spleen. Journal of Experimental Biology, 209 (14). pp. 2734-2738.

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Abstract

Erythropoietin (EPO) is a glycoprotein hormone that regulates the proliferation and differentiation of erythroid progenitor cells in mammals. Although EPO has been identified in fish, the specific function and effects of hypoxia have not been investigated previously. In this study, we have demonstrated a relationship between increases in renal EPO levels and decreases in spleen EPO levels and spleen-somatic index (SSI), with increases in haemoglobin (Hb) concentration in the blood during hypoxia exposure in rainbow trout. Splenic contraction and the subsequent red blood cell release accounts for the initial increase in Hb concentration in the blood, whereas EPO action probably accounts for the later increases in hemoglobin concentration in the blood. Our data indicate that fish and mammalian erythropoietic systems are similar in response to hypoxia, in that erythropoiesis in fish is influenced by EPO.

Item ID: 45327
Item Type: Article (Refereed Research - C1)
Keywords: erythropoietin, erythropoiesis, hypoxia, rainbow trout, Oncorhynchus mykiss, red blood cells, spleen somatic index
ISSN: 1477-9145
Funders: City University of Hong Kong (CUHK), Areas of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE)
Projects and Grants: CUHK Project no. 7001585-740, AoE Project No. AoE/P-04/2004
Date Deposited: 05 Sep 2016 22:25
FoR Codes: 06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060303 Biological Adaptation @ 50%
06 BIOLOGICAL SCIENCES > 0602 Ecology > 060203 Ecological Physiology @ 50%
SEO Codes: 96 ENVIRONMENT > 9603 Climate and Climate Change > 960301 Climate Change Adaptation Measures @ 100%
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