High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover
Neller, M.A., Burrows, J.M., Rist, M.J., Miles, J.J., and Burrows, S.R. (2013) High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover. Journal of Virology, 87 (1). pp. 697-700.
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Abstract
High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little.
| Item ID: | 45181 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1098-5514 |
| Funders: | National Health and Medical Research Council (NHMRC) |
| Projects and Grants: | NHMRC APP1031652, NHMRC APP1021452, NHMRC APP389830 |
| Date Deposited: | 16 Aug 2016 04:42 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100% |
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