Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Sirisoontorn, Irin, Hotokezaka, Hitoshi, Hashimoto, Megumi, Gonzales, Carmen, Luppanapornlarp, Suwannee, Darendeliler, M. Ali, and Yoshida, Noriaki (2012) Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid. American Journal of Orthodontics and Dentofacial Orthopedics, 141 (5). pp. 563-573.

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Abstract

Introduction: The effect of zoledronic acid, a potent and novel bisphosphonate, on tooth movement and orthodontically induced root resorption in osteoporotic animals systemically treated with zoledronic acid as similarly used in postmenopausal patients has not been elucidated. Therefore, this study was undertaken.

Methods: Fifteen 10-week-old female Wistar rats were divided into 3 groups: ovariectomy, ovariectomy + zoledronic acid, and control. Only the ovariectomy and ovariectomy + zoledronic acid groups underwent ovariectomies. Two weeks after the ovariectomy, zoledronic acid was administered only to the ovariectomy + zoledronic acid group. Four weeks after the ovariectomy, 25-g nickel-titanium closed-coil springs were applied to observe tooth movement and orthodontically induced root resorption.

Results: There were significant differences in the amounts of tooth movement and orthodontically induced root resorption between the ovariectomy and the control groups, and also between the ovariectomy and the ovariectomy + zoledronic acid groups. There was no statistically significant difference in tooth movement and orthodontically induced root resorption between the ovariectomy + zoledronic acid and the control groups. Zoledronic acid inhibited significantly more tooth movement and significantly reduced the severity of orthodontically induced root resorption in the ovariectomized rats. The ovariectomy + zoledronic acid group showed almost the same results as did the control group in both tooth movement and orthodontically induced root resorption.

Conclusions: Zoledronic acid inhibits excessive orthodontic tooth movement and also reduces the risk of severe orthodontically induced root resorption in ovariectomized rats.

Item ID: 45164
Item Type: Article (Research - C1)
ISSN: 1097-6752
Keywords: orthodontic tooth movement; root resorption; zoledronic acid
Date Deposited: 16 Aug 2016 23:39
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110506 Orthodontics and Dentofacial Orthopaedics @ 70%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110320 Radiology and Organ Imaging @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920402 Dental Health @ 50%
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