Multivariate analysis using high definition flow cytometry reveals distinct T cell repertoires between the fetal–maternal interface and the peripheral blood
Neller, Michelle A., Santner-Nanan, Brigitte, Brennan, Rebekah M., Hsu, Peter, Joung, Steven, Nanan, Ralph, Burrows, Scott R., and Miles, John J. (2014) Multivariate analysis using high definition flow cytometry reveals distinct T cell repertoires between the fetal–maternal interface and the peripheral blood. Frontiers in Immunology, 5. 33. pp. 1-6.
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Abstract
The human T cell compartment is a complex system and while some information is known on repertoire composition and dynamics in the peripheral blood, little is known about repertoire composition at different anatomical sites. Here, we determine the T cell receptor beta variable (TRBV) repertoire at the decidua and compare it with the peripheral blood during normal pregnancy and pre-eclampsia. We found total T cell subset disparity of up to 58% between sites, including large signature TRBV expansions unique to the fetal–maternal interface. Defining the functional nature and specificity of compartment-specific T cells will be necessary if we are to understand localized immunity, tolerance, and pathogenesis.
| Item ID: | 45061 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 1664-3224 |
| Keywords: | T cell repertoire, pregnancy, decidual mononuclear cells, pre-eclampsia |
| Additional Information: | © 2014 Neller, Santner-Nanan, Brennan, Hsu, Joung, Nanan, Burrowsm and Miles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. https://creativecommons.org/licenses/by/3.0/ |
| Funders: | Australian National Health and Medical Research Council (NHMRC), Australian Women and Children's Research Foundation (OZWAC), Nepean Medical Research Foundation (NMRF) |
| Date Deposited: | 10 Aug 2016 02:26 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100% |
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