Brennan, Rebekah M., Burrows, Jacqueline M., Elliott, Thomas, Neller, Michelle A., Gras, Stephanie, Rossjohn, Jamie, Miles, John J., and Burrows, Scott J. (2014) Missense single nucleotide polymorphisms in the human T cell receptor loci control variable gene usage in the T cell repertoire. British Journal of Haematology, 166 (1). pp. 148-152.

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Abstract

[Extract] T cells play a central role in immunity as both regulators and effectors of immune function, following recognition of antigenic peptides presented by human leucocyte antigens (HLA) via the αβ T cell receptor (TCR). As such, the genes that encode the TCR have long been considered candidates for disease association. The human TCR is assembled from a total of 174 gene segments on chromosomes 7 and 14. Each α-chain is encoded by a variable (TRAV), a joining and a constant gene, while each β-chain is encoded by a variable (TRBV), a diversity, a joining and a constant gene (Davis & Bjorkman, 1988).

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