Jennings, Ernest A., and Bell, Shenade J. (2016) Dental pain: is ATP the key mediator? Journal of Dentistry, Oral Health and Cosmesis, 1 (1). 4. pp. 1-3.

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Abstract

Dental pain has a significant impact on the population and the mechanisms remain poorly understood. However, there is accumulating evidence that purinergic receptors are key contributors in central and peripheral dental nociception mechanisms. These purine receptors are localized in the trigeminal sensory neurons and are activated by Adenosine 5' Tri-Phosphate (ATP), which is thought to be a primary mediator in dental pain. Recent evidence has implicated purinergic receptors in persistent pain states. This includes increased sensitivity to ATP in satellite glia cells (which surround the trigeminal sensory neuron cell bodies), and reports of ATP signaling between dentin producing odontoblasts and trigeminal sensory neurons. This article will briefly summarize the importance of the purinergic receptor and ATP as a key mediator in the mechanisms of dental pain.

Item ID:	44970
Item Type:	Article (Commentary)
ISSN:	2473-6783
Date Deposited:	13 Jan 2017 00:45
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110502 Dental Therapeutics, Pharmacology and Toxicology @ 60% 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110902 Cellular Nervous System @ 40%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 50% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 50%
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