Photostability of triprolidine hydrochloride and its mixtures with cyclodextrin and glucose

Ndlebe, V.J., Brown, M.E., and Glass, B.D. (2004) Photostability of triprolidine hydrochloride and its mixtures with cyclodextrin and glucose. Journal of Thermal Analysis and Calorimetry, 77 (2). pp. 459-470.

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Triprolidine hydrochloride, C19H22N2·HCl·H2O (TPH) is a well-known antihistamine drug, which is reported as being photosensitive. Solid-state photostability studies of TPH were undertaken by irradiating TPH and its binary mixtures with β-cyclodextrin (BCD) and glucose, using an Atlas Suntest CPS+ irradiation chamber and conditions according to the guidelines of the International Committee on Harmonization (ICH). HPLC analysis was used to determine the extent of photodegradation. XRD results showed that changes in the TPH crystal structure had occurred during irradiation and that these changes increased with the time of irradiation. Although the potential for isomerization under the influence of UV-light to the pharmaceutically inactive Z-isomer exists, results have proved that this transformation for solid-state TPH would require more extreme light conditions. The results of this study thus illustrate the general light stability of TPH in the solid-state.

Item ID: 4485
Item Type: Article (Research - C1)
ISSN: 1572-8943
Keywords: cyclodextrins; excipients; glucose; photostability; tripolidine; tripolidine hydrochloride
Date Deposited: 10 Jun 2009 02:36
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences @ 100%
SEO Codes: 86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860899 Human Pharmaceutical Products not elsewhere classified @ 100%
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