Statin therapy and plasma vitamin E concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials

Sahebkar, Amirhossein, Simental-Mendía, Luis E., Ferretti, Gianna, Bacchetti, Tiziana, and Golledge, Jonathan (2015) Statin therapy and plasma vitamin E concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials. Atherosclerosis, 243 (2). pp. 579-588.

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Abstract

Background: Vitamin E is one of the most important natural antioxidants, and its plasma levels are inversely associated with the progression of atherosclerosis. There have been reports suggesting a potential negative effect of statin therapy on plasma vitamin E levels. The aim of this meta-analysis was to determine the impact of statin therapy on plasma vitamin E concentrations.

Methods: PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched to identify randomized placebo-controlled trials evaluating the impact of statins on plasma vitamin E concentrations from inception to February 27, 2015. A systematic assessment of bias in the included studies was performed using the Cochrane criteria. A random-effects model (using DerSimonian-Laird method) and the generic inverse variance method were used to examine the effect of statins on plasma vitamin E concentrations. Heterogeneity was quantitatively assessed using the I2 index. Sensitivity analysis was conducted using the leave-one-out method.

Results: A meta-analysis of data from 8 randomized treatment arms including 504 participants indicated a significant reduction in plasma vitamin E concentrations following statin treatment (WMD: −16.30%, 95% CI: −16.93, −15.98, p < 0.001). However, cholesterol-adjusted vitamin E concentrations (defined as vitamin E:total cholesterol ratio) were found to be improved by statin therapy (WMD: 29.35%, 95% CI: 24.98, 33.72, p < 0.001). Statin therapy was not associated with any significant alteration in LDL vitamin E content (SMD: 0.003, 95% CI: −0.90, 0.90, p = 0.995).

Conclusion: Findings of the present study suggest that statin therapy has no negative impact on plasma vitamin E concentrations or LDL vitamin E content.

Item ID: 44414
Item Type: Article (Research - C1)
ISSN: 1879-1484
Keywords: alpha-tocopherol; hydroxymethylglutaryl CoA reductase inhibitors; lipoprotein; dyslipidemia; cardiovascular disease
Date Deposited: 15 Jun 2016 02:53
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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