Proportion of undercarboxylated osteocalcin and serum P1NP predict incidence of myocardial infarction in older men

Yeap, Bu B., Alfonso, Helman, Chubb, S.A. Paul, Byrnes, Elizabeth, Beilby, John P., Ebeling, Peter R., Allan, Carolyn A., Schultz, Carl, Hankey, Graeme J., Golledge, Jonathan, Flicker, Leon, and Norman, Paul E. (2015) Proportion of undercarboxylated osteocalcin and serum P1NP predict incidence of myocardial infarction in older men. Journal of Clinical Endocrinology and Metabolism, 100 (10). pp. 3934-3942.

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Abstract

Context: Undercarboxylated osteocalcin (ucOC) modulates insulin secretion and sensitivity in mice, and higher ucOC is associated with lower prevalence of diabetes in men. The influence of ucOC distinct from other markers of bone turnover on incidence of cardiovascular events is unclear.

Participants: Community-dwelling men aged 70–89 years resident in Perth, Western Australia.

Main Outcome Measures: Serum total osteocalcin (TOC), N-terminal propeptide of type I collagen (P1NP), and collagen type I C-terminal cross-linked telopeptide (CTX) were measured by immunoassay, and ucOC by hydroxyapatite binding. The ratio ucOC/TOC was calculated. Hospital admissions and deaths from myocardial infarction (MI) and stroke were ascertained.

Results: There were 3384 men followed for 7.0 years, during which 293 experienced an MI, 251 stroke, and 2840 neither. In multivariate analyses, higher ratio of ucOC/TOC (expressed as %) was associated with lower incidence of MI (quartiles Q2–4, ≥49% versus Q1,<49%, hazard ratio 0.70, 95% confidence interval = 0.54–0.91), but not of stroke (0.99, 0.73–1.34). Higher P1NP was associated with higher incidence of MI (Q2–4, ≥28.2 μg/L versus Q1, <28.2 μg/L, hazard ratio 1.45, 95% confidence interval = 1.06–1.97), but not of stroke (0.94, 0.70–1.26). CTX was not associated with incident MI or stroke.

Conclusions: A reduced proportion of undercarboxylated osteocalcin or higher P1NP are associated with increased incidence of MI. UcOC/TOC ratio and P1NP predict risk of MI but not stroke, in a manner distinct from CTX. Further studies are needed to investigate potential mechanisms by which bone turnover markers related to metabolic risk and to collagen formation could modulate cardiovascular risk.

Item ID: 44375
Item Type: Article (Research - C1)
ISSN: 1945-7197
Date Deposited: 17 Jun 2016 00:57
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 60%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111702 Aged Health Care @ 40%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 80%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 20%
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