The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug
Davies, Murray S., Berners-Price, Susan J., Cox, John W., and Farrell, Nicholas (2003) The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug. Chemical Communications, 1. pp. 122-123.
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DOI: 10.1039/b209661g
View at Publisher Website: http://dx.doi.org/10.1039/b209661g
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Abstract
The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.
| Item ID: | 4435 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1364-548X |
| Keywords: | aquation; chemotherapy; DNA; platinum |
| Date Deposited: | 16 Jun 2009 03:28 |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100% |
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