Sharma, C.G. Dileep, and Pradeep, A.R. (2006) Anti-neutrophil cytoplasmis autoantibodies: a renewed paradigm in periodontal disease pathogenesis? Journal of Periodontology, 77 (8). pp. 1304-1313.

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Abstract

In the past, various models including the autoimmunity model have been proposed to explain the pathogenesis of periodontal diseases. The aim of this review is to introduce the pathogenic role of anti-neutrophil cytoplasmic autoantibodies (ANCAs) in various autoimmune diseases and compare these conditions with periodontal disease to elucidate common pathogenic mechanisms. Also, a novel model to explain the pathogenesis of periodontal disease based on the concept of ANCA-associated autoimmunity is proposed. This encompasses a wide array of biochemical mediators that range from direct and indirect initiators of ANCA production and eventual release of proinflammatory mediators and free radicals, all of which have been implicated in periodontal tissue destruction in the past. In addition, specific links between the typical ANCA-associated diseases and periodontal disease are discussed. Finally, a new paradigm in the periodontal disease-associated destruction is proposed that includes the currently accepted mechanism, namely, the genetic-microbial-host interactions.

Item ID:	44291
Item Type:	Article (Research - C1)
ISSN:	0022-3492
Keywords:	autoantibody; beta glucuronidase; cathepsin B; cathepsin D; collagenase; elastase; free radical; gelatinase; granulocyte macrophage colony stimulating factor; HLA antigen; interleukin 1beta; lysozyme; matrix metalloproteinase; myeloperoxidase; neutrophil cytoplasmic antibody; reactive oxygen metabolite; superantigen; tumor necrosis factor alpha; bacterial antigen; neutrophil cytoplasmic antibody; reactive oxygen metabolite; superantigen, antibody detection; antibody production; apoptosis; autoimmune disease; autoimmunity; cell damage; cytokine production; enzyme activity; genetic risk; host pathogen interaction; human; immunopathogenesis; leukocyte activation; neutrophil; periodontal disease; regulatory mechanism; review; rheumatoid arthritis; systemic lupus erythematosus; tissue injury; autoimmune disease; enzymology; immunology; metabolism; periodontal disease, antibodies, antineutrophil cytoplasmic; antigens, bacterial; apoptosis; autoimmune diseases; humans; neutrophils; periodontal diseases; reactive oxygen species; superantigens
Date Deposited:	07 Oct 2016 03:51
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110508 Periodontics @ 80% 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 20%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 80% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 20%
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