Vaccination against periodontitis: The saga continues

Sharma, Dileep, Prasad, Shiva, and Karthikeyan, Bangalore Varadhan (2007) Vaccination against periodontitis: The saga continues. Expert Review of Vaccines, 6 (4). pp. 579-590.

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Periodontal disease can be considered to be one of the most common chronic inflammatory diseases inflicting humans. With the advent of advanced molecular diagnostic techniques, a better understanding of the role of specific pathogens and the contributory role of the host immune response in the initiation and progression of periodontal disease has been possible - although not completely. However, successful vaccine development that fully utilizes the current level of understanding has not yet occurred for human use. This paper reviews various in vitro, animal studies and human trials undertaken to develop a vaccine against periodontal disease, with emphases on the shortfalls of these efforts and future prospects of developing a successful vaccine against periodontal disease.

Item ID: 44285
Item Type: Article (Research - C1)
ISSN: 1744-8395
Keywords: Actinobacillus actinomycetemcomitans; adhesins; adjuvant therapy; animals; antibodies; bacterial antigen; bacterial capsules; bacterial polysaccharide; bacterial vaccine; bacterial vector; bacterial; bacterium adherence; capsular polysaccharide; cell envelope antigen; cell wall antigen; cholera toxin; clinical feature; Cysteine Endopeptidases; cysteine proteinase; dental plaque; diagnostic procedure; DNA hybridization; drug carrier; drug formulation; drug mechanism; drug structure; drug synthesis; drug targeting; fimbria protein; fimbria; fimbriae proteins; gingipain R; humans; humoral immunity; immune response; immunization; immunomodulation; immunotherapy; in vitro study; medical research; monoclonal antibody 61bg13; monoclonal antibody hab omp1; monoclonal antibody hemagglutinin domain; monoclonal antibody; monoclonal; mycobacterium vaccae vaccine; nonhuman; passive; pathogenesis; periodontitis; periodontitis; pg32 antigen; pg33 antigen; plantibody; porphypain 2; porphyromonas gingivalis vaccine; porphyromonas gingivalis; prophylaxis; rabbit antiserum; radio diagnosis; review; unclassified drug; vaccination; vaccines
Date Deposited: 19 Sep 2016 23:57
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110508 Periodontics @ 80%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 80%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920402 Dental Health @ 20%
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