Endothelial transcriptomic analysis

Sharma, Dileep, Hamlet, Stephen, Petcu, Eugen, and Ivanovski, Saso (2015) Endothelial transcriptomic analysis. In: Slevin, Mark, and McDowell, Garry, (eds.) Handbook of Vascular Biology Techniques. Springer, Dordrecht, Netherlands, pp. 417-426.

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The genetic makeup of an individual is unique, termed genome and is stored in the nucleus of each cell. Genome is made up of deoxyribonucleic acid (DNA) a long, helical molecule that consists of instructions essential for formation and maintenance of cells. These instructions from the DNA are then transcribed into corresponding molecules of ribonucleic acid (RNA), termed as transcripts. A transcriptome essentially is a collection of all the transcripts within a given cell and the qualitative and quantitative evaluation of transcriptome is termed transcriptomics. Various "–omics" have been recently described in molecular biology including genomics or detection of total genes, transcriptomics or gene-expression profiling, proteomics or detection of proteins and metabolomics or detection of metabolites in a biological sample. A cell contains various types of RNA including ribosomal (rRNA), transfer (tRNA), and messenger (mRNA). mRNA is the principal type and most abundant RNA involved in delivering the specific gene-transcribed message to ribosomes, the molecular factories located in the cytoplasm that produces (translates) the corresponding protein.

Item ID: 44278
Item Type: Book Chapter (Reference)
ISBN: 978-94-017-9715-3
Date Deposited: 29 Nov 2016 00:37
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110105 Medical Biochemistry: Nucleic Acids @ 50%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 50%
92 HEALTH > 9202 Health and Support Services > 920203 Diagnostic Methods @ 50%
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