Sharma, C.G. Dileep, and Pradeep, A.R. (2007) Localized attachment loss in Pendred syndrome: incidental? Journal of Periodontology, 78 (5). pp. 948-954.

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Abstract

Background: Pendred syndrome is a rare, inherited, autosomal recessive disorder with an iodine organification defect of thyroxin produced by the thyroid gland. Its clinical features include sensorineural hearing loss, classically congenital and prelingual, and goiter.

Methods: This is the first case report of Pendred syndrome in the dental literature with oral findings that include localized extensive attachment loss involving mandibular incisor teeth and idiopathic hypercementosis involving multiple teeth in addition to other oral manifestations, suggesting hypothyroidism-like macroglossia and macrocheilia. Furthermore, serum alkaline phosphatase along with inorganic calcium and phosphate levels were also elevated. Peripheral neutrophil function test suggested a defective function of neutrophils.

Results: Management of the case included augmenting thyroxin supplementation, in consultation with an endocrinologist, and extraction of hopeless mandibular central incisors followed by placement of immediate transitional dentures.

Conclusion: A comprehensive medical history and systemic and laboratory evaluations should be considered a prerequisite to identify, manage, and report such rare conditions in routine clinical practice.

Item ID:	44271
Item Type:	Article (Research - C1)
ISSN:	1943-3670
Keywords:	Autosomal recessive, goiter, hypercementosis, hypothyroidism, periodontitis, sensorineural hearing loss
Date Deposited:	14 Sep 2016 05:12
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110508 Periodontics @ 80% 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110505 Oral Medicine and Pathology @ 20%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 80% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920106 Endocrine Organs and Diseases (excl. Diabetes) @ 20%
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