Animal models for bisphosphonate-related osteonecrosis of the jaws: an appraisal

Sharma, D., Hamlet, S., Petcu, E., and Ivanovski, S. (2013) Animal models for bisphosphonate-related osteonecrosis of the jaws: an appraisal. Oral Diseases, 19 (8). pp. 747-754.

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The prolonged use of bisphosphonates has been shown to cause a condition termed ‘bisphosphonate related osteonecrosis of the jaws’ (BRONJ). BRONJ is a disease entity which has only been described relatively recently, and its multi-factorial aetiology is yet to be fully elucidated. Therefore, the treatment of BRONJ lesions remains a challenge, and animal models are necessary to assist researchers in better understanding the disease. This has led to the recent publication of a number of studies utilising a variety of animal models of BRONJ. This review outlines the factors to be considered when selecting an animal model for BRONJ and discusses the current literature in this rapidly progressing field of research. It is important to consider the applicability of a given model to the clinical condition presenting in humans, and to this end, thorough characterisation of the clinical, histological, radiographic and systemic features is necessary. The development of a clinical lesion is an important consideration in terms of choosing a relevant model, and it appears clear that surgical manipulation, generally involving tooth extraction, is necessary for successful induction of the classic ‘clinical’ lesion of BRONJ.

Item ID: 44265
Item Type: Article (Research - C1)
ISSN: 1601-0825
Keywords: animal models; bisphosphonates; BRONJ; osteonecrosis
Date Deposited: 16 Jun 2016 00:45
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110502 Dental Therapeutics, Pharmacology and Toxicology @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110509 Special Needs Dentistry @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110505 Oral Medicine and Pathology @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 100%
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