Taki, Aya, and Smooker, Peter (2015) Small wonders: the use of nanoparticles for delivering antigen. Vaccines, 3 (3). pp. 638-661.

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Abstract

Despite the discovery of many potential antigens for subunit vaccines, universal protection is often lacking due to the limitations of conventional delivery methods. Subunit vaccines primarily induce antibody-mediated humoral responses, whereas potent antigen-specific cellular responses are required for prevention against some pathogenic infections. Nanoparticles have been utilised in nanomedicine and are promising candidates for vaccine or drug delivery. Nanoparticle vehicles have been demonstrated to be efficiently taken up by dendritic cells and induce humoral and cellular responses. This review provides an overview of nanoparticle vaccine development; in particular, the preparation of nanoparticles using a templating technique is highlighted, which would alleviate some of the disadvantages of existing nanoparticles. We will also explore the cellular fate of nanoparticle vaccines. Nanoparticle-based antigen delivery systems have the potential to develop new generation vaccines against currently unpreventable infectious diseases.

Item ID:	44239
Item Type:	Article (Research - C1)
ISSN:	2076-393X
Keywords:	nanoparticle; antigen delivery; templating system; adjuvant
Additional Information:	This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Funders:	CASS Foundation
Date Deposited:	07 Jun 2016 01:08
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 50% 10 TECHNOLOGY > 1007 Nanotechnology > 100709 Nanomedicine @ 50%
SEO Codes:	86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860801 Human Biological Preventatives (e.g. Vaccines) @ 100%
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