Exercise during short-term and long-term continuous exposure to hypoxia exacerbates sleep-related periodic breathing

Tellez, Helio Fernandez, Morrison, Shawnda A., Neyt, Xavier, Mairesse, Olivier, Piacentini, Maria Francesca, Macdonald-Nethercott, Eoin, Pangerc, Andrej, Dolenc-Groselj, Leja, Eiken, Ola, Pattyn, Nathalie, Mekjavic, Igor B., and Meeusen, Romain (2016) Exercise during short-term and long-term continuous exposure to hypoxia exacerbates sleep-related periodic breathing. Sleep, 39 (4). pp. 773-783.

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Abstract

Study Objectives: Exposure to hypoxia elevates chemosensitivity, which can lead to periodic breathing. Exercise impacts gas exchange, altering chemosensitivity; however, interactions between sleep, exercise and chronic hypoxic exposure have not been examined. This study investigated whether exercise exacerbates sleep-related periodic breathing in hypoxia.

Methods: Two experimental phases. Short-Term Phase: a laboratory controlled, group-design study in which 16 active, healthy men (age: 25 +/- 3 y, height: 1.79 +/- 0.06 m, mass: 74 +/- 8 kg) were confined to a normobaric hypoxic environment (FIO2 = 0.139 +/- 0.003, 4,000 m) for 10 days, after random assignment to a sedentary (control, CON) or cycle-exercise group (EX). Long-Term Phase: conducted at the Concordia Antarctic Research Station (3,800 m equivalent at the Equator) where 14 men (age: 36 +/- 9 y, height: 1.77 +/- 0.09 m, mass: 75 +/- 10 kg) lived for 12-14 months, continuously confined. Participants were stratified post hoc based on self-reported physical activity levels. We quantified apnea-hypopnea index (AHI) and physical activity variables.

Results: Short-Term Phase: mean AHI scores were significantly elevated in the EX group compared to CON (Night1 = CON: 39 +/- 51, EX: 91 +/- 59; Night10 = CON: 32 +/- 32, EX: 92 +/- 48; P = 0.046). Long-Term Phase: AHI was correlated to mean exercise time (R-2 = 0.4857; P = 0.008) and the coefficient of variation in night oxyhemoglobin saturation (SpO(2); R-2 = 0.3062; P = 0.049).

Conclusions: Data indicate that exercise (physical activity) per se affects night SpO(2) concentrations and AHI after a minimum of two bouts of moderateintensity hypoxic exercise, while habitual physical activity in hypobaric hypoxic confinement affects breathing during sleep, up to 13+ months' duration

Item ID: 44036
Item Type: Article (Research - C1)
ISSN: 1550-9109
Keywords: Antarctica, sleep apnea, confinement, cycling, high altitude, oxygen saturation
Funders: Slovene National Research Agency (ARRS), Michael Smith Foundation for Health Research (MSFHR), European Space Agency (ESA)
Projects and Grants: ARRS L3-4328, ARRS L3-3654, ARRS P3-0338, MSFHR Fellowship ST-PDF-03269(11-1) CLIN, ESA PRODEX program AIIESA17
Date Deposited: 27 Apr 2016 07:32
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1116 Medical Physiology > 111602 Human Biophysics @ 100%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920504 Occupational Health @ 100%
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