The role of anti-myosin antibodies in perpetuating cardiac damage following myocardial infarction

O'Donohoe, Tom J., Schrale, Ryan G., and Ketheesan, Natkunam (2016) The role of anti-myosin antibodies in perpetuating cardiac damage following myocardial infarction. International Journal of Cardiology, 209. pp. 226-233.

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Abstract

Recent improvements in the medical and surgical management of myocardial infarction mean that many patients are now surviving with greater impairment of cardiac function. Despite appropriate management, some of these patients subsequently develop pathological ventricular remodelling, which compounds their contractile dysfunction and can lead to congestive cardiac failure (CCF). The pathophysiological mechanism underpinning this process remains incompletely understood. One hypothesis suggests that a post-infarction autoimmune response, directed against constituents of cardiac myocytes, including cardiac myosin, may make an important contribution. Our review summarises the current literature related to the formation and clinical relevance of anti myosin antibodies (AMAs) in patients with myocardial infarction. This discussion is supplemented with reference to a number of important animal studies, which provide evidence of the potential mechanisms underlying AMA formation and autoantibody mediated cardiac dysfunction.

Item ID: 43999
Item Type: Article (Research - C1)
ISSN: 1874-1754
Keywords: myocardial infarction, anti-myosin antibodies, autoimmunity, ischaemic heart disease, autoantibody
Funders: Townsville Hospital and Health Service (THHS)
Projects and Grants: THHS RG/2015/13
Date Deposited: 27 Apr 2016 07:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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