Overcoming treatment resistance in cancer: current understanding and tactics

Wu, Guang, Wilson, George, George, Jacob, Liddle, Christopher, Hebbard, Lionel, and Liang, Qiao (2017) Overcoming treatment resistance in cancer: current understanding and tactics. Cancer Letters, 387. pp. 69-76.

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Abstract

Chemotherapy is the standard treatment for many, if not all, metastatic cancers. While chemotherapy is often capable of inducing cell death in tumors leading to shrinkage of the tumor bulk, many patients suffer from recurrence and ultimately death due to resistance. During the last decade, treatment resistance has attracted great attention followed by some seminal discoveries, including sequential mutations, cancer stem cells, and bidirectional inter-conversion of stem and non-stem cancer cell populations. Nevertheless, the successful treatment of cancer will require a considerable refinement of our knowledge concerning treatment resistance. In doing so, we expect that a more informed and refined approach to treat cancer will be developed and this may improve prognosis of cancer patients. In this review, we will discuss the current knowledge concerning the failure of cancer treatments and the potential approaches to overcome therapeutic resistance.

Item ID: 43762
Item Type: Article (Research - C1)
ISSN: 1872-7980
Keywords: treatment resistance, cancer stem cells, cancer progression, mutation, EMT, EMT transition
Funders: Sydney Medical Foundation (SMF), University of Sydney (US), National Health and Medical Research Council of Australia (NHMRC), Cancer Council of New South Wales (CC)
Projects and Grants: NHMRC Program grant APP1053206, NHMRC Project grant APP1047417, NHMRC Project grant APP1087297, CC Project grant APP1070076, CC Project grant APP1069733
Date Deposited: 12 Jul 2016 02:48
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111209 Solid Tumours @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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