Current advances of murine models for food allergy

Liu, Tiange, Navarro, Severine, and Lopata, Andreas L. (2016) Current advances of murine models for food allergy. Molecular Immunology, 70. pp. 104-117.

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Abstract

Food allergy affects an increasing population in Western world but also developing countries. Researchers have been taking great efforts in identifying and characterising food allergens using molecular tools. However, there are still many mechanistic hypotheses that need to be tested using an appropriate in vivo experimental platform. To date, a number of mouse models for food allergy have been established and provided valuable insights into food allergenicity, development of therapies and allergic inflammation mechanisms. Nevertheless, a large diversity of protocols have been developed for the establishment of relevant mouse models. As a result, comparisons of outcomes between different models are very difficult to be conducted. The phenotypes of mouse models are greatly influenced by genetic background, gender, route of allergen exposure, the nature and concentration of food allergens, as well as the usage of adjuvants. This review focuses on IgE-mediated food allergy, compares the differential approaches in developing appropriate murine models for food allergy and details specific findings for three major food allergens, peanut, milk and shellfish.

Item ID: 43730
Item Type: Article (Research - C1)
ISSN: 1872-9142
Keywords: food allergy, mouse model establishment, Th2 responses
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A version of this publication was included as Chapter 1 of the following PhD thesis: Liu, Tiange (2017) Development of a mouse model to evaluate the degree of immunological cross-reactivity between prawns and abalone. PhD thesis, James Cook University, which is available Open Access in ResearchOnline@JCU. Please see the Related URLs for access.

Funders: China Scholarship Council (CSC), Australian Institute of Tropical Health and Medicine (AITHM), Australian Research Council (ARC)
Date Deposited: 12 Aug 2016 04:05
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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