The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation

Zaiss, Mario M., Rapin, Alexis, Lebon, Luc, Dubey, Lalit Kumar, Mosconi, Ilaria, Sarter, Kerstin, Piersigilli, Alessandra, Menin, Laure, Walker, Alan W., Rougemont, Jacques, Paerewijck, Oonagh, Geldhof, Peter, McCoy, Kathleen D., Macpherson, Andrew J., Croese, John, Giacomin, Paul R., Loukas, Alex, Junt, Tobias, Marsland, Benjamin J., and Harris, Nicola L. (2015) The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation. Immunity, 43 (5). pp. 998-1010.

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Abstract

Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or whether it also involved crosstalk with the local microbiota. We report that chronic infection with the murine helminth Heligmosomoides polygyrus bakeri (Hpb) altered the intestinal habitat, allowing increased short chain fatty acid (SCFA) production. Transfer of the Hpb-modified microbiota alone was sufficient to mediate protection against allergic asthma. The helminth-induced anti-inflammatory cytokine secretion and regulatory T cell suppressor activity that mediated the protection required the G protein-coupled receptor (GPR)-41. A similar alteration in the metabolic potential of intestinal bacterial communities was observed with diverse parasitic and host species, suggesting that this represents an evolutionary conserved mechanism of host-microbe-helminth interactions.

Item ID: 43641
Item Type: Article (Research - C1)
ISSN: 1097-4180
Additional Information:

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Date Deposited: 14 Apr 2016 03:44
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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