Hepatocellular carcinoma and non-alcoholic steatohepatitis: the state of play

Charrez, Bérénice, Qiao, Liang, and Hebbard, Lionel (2016) Hepatocellular carcinoma and non-alcoholic steatohepatitis: the state of play. World Journal of Gastroenterology, 22 (8). pp. 2494-2502.

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Hepatocellular carcinoma (HCC) is now the fifth cancer of greatest frequency and the second leading cause of cancer related deaths worldwide. Chief amongst the risks of HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The latter can promote non-alcoholic fatty liver disease (NAFLD), that can lead to the inflammatory form non-alcoholic steatohepatitis (NASH), and can in turn promote HCC. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give a summary of the recent findings that describe and associate NAFLD and NASH with the subsequent HCC progression. We will focus our discussion on clinical and genomic associations that describe new risks for NAFLD and NASH promoted HCC. In addition, we will consider novel murine models that clarify some of the mechanisms that drive NASH HCC formation.

Item ID: 43569
Item Type: Article (Research - C1)
ISSN: 2219-2840
Keywords: non-alcoholic steatohepatitis, hepatocellular carcinoma, non-alcoholic fatty liver disease, models, mice
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Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

Funders: Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney (RWSB), National Health and Medical Research Council of Australia (NHMRC), Cancer Council NSW (CC)
Projects and Grants: NHMRC Project Grant 1047417, NHMRC Project Grant 1087297, CC Project Grant 1070076, CC Project Grant 1069733
Date Deposited: 28 Jul 2016 23:44
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321111 Solid tumours @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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