Aptamers: a promising chemical antibody for cancer therapy

Zhou, Gang, Wilson, George, Hebbard, Lionel, Duan, Wei, Liddle, Christopher, George, Jacob, and Qiao, Liang (2016) Aptamers: a promising chemical antibody for cancer therapy. Oncotarget, 7 (12). pp. 13446-13463.

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Abstract

Aptamers, also known as chemical antibodies, are single-stranded nucleic acid oligonucleotides which bind to their targets with high specificity and affinity. They are typically selected by repetitive in vitro process termed systematic evolution of ligands by exponential enrichment (SELEX). Owing to their excellent properties compared to conventional antibodies, notably their smaller physical size and lower immunogenicity and toxicity, aptamers have recently emerged as a new class of agents to deliver therapeutic drugs to cancer cells by targeting specific cancer-associated hallmarks. Aptamers can also be structurally modified to make them more flexible in order to conjugate other agents such as nano-materials and therapeutic RNA agents, thus extending their applications for cancer therapy. This review presents the current knowledge on the practical applications of aptamers in the treatment of a variety of cancers.

Item ID: 43568
Item Type: Article (Scholarly Work)
ISSN: 1949-2553
Keywords: aptamers, SELEX, siRNA, cancers, target therapy
Additional Information:

Creative Commons License: All OncoTarget site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.

Funders: Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney (RWSB), Cancer Council NSW (CC), National Health and Medical Research Council (NHMRC), Cancer Institute NSW (CI)
Projects and Grants: CC Grant ID: APP1070076, NHMRC 1053206, NHMRC 632630, NHMRC 1049857, CI Sydney West Translational Cancer Research Centre grant
Date Deposited: 29 Jul 2016 00:21
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111209 Solid Tumours @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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