The impact of prior flavivirus infections on the development of Type 2 Diabetes among the Indigenous Australians

Sorenson, Alanna, Owens, Leigh, Caltabiano, Marie, Cadet-James, Yvonne, Hall, Roy, Govan, Brenda, and Clancy, Paula (2016) The impact of prior flavivirus infections on the development of Type 2 Diabetes among the Indigenous Australians. American Journal of Tropical Medicine and Hygiene, 95 (2). pp. 265-268.

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It is estimated that 5% of Australians over the age of 18 have diabetes, with the number of new cases increasing every year. Type 2 diabetes (T2D) also represents a significant disease burden in the Australian Indigenous population, where prevalence is three times greater than that of non-Indigenous Australians.Prevalence of T2D has been found to be higher in rural and remote Indigenous Australian populations compared to urban Indigenous Australian populations.Several studies have also found that body mass index (BMI) and waist circumference (WC) are not appropriate for prediction of T2D risk in Indigenous Australians. Regional and remote areas of Australia are endemic for a variety of mosquito-borne flaviviruses.Studies that have investigated seroprevalence of flaviviruses in remote Aboriginal communities have found high proportions of seroconversion. The family Flaviviridae comprises several genera of viruses with non-segmented single-stranded positive sense RNA genomes, and includes the flaviviruses and hepaciviruses. Hepatitis C virus (HCV) has been shown to be associated with insulin resistance and subsequent development of T2D. Flaviviruses and HCV possess conserved proteins and subgenomic RNA structures that may play similar roles in the development of insulin resistance. While dietary and lifestyle factors are associated with increased risk of developing T2D, the impact of infectious diseases such as arboviruses has not been assessed. Flaviviruses circulating in Indigenous Australian communities may play a significant role in inducing glucose intolerance and exacerbating T2D.

Item ID: 43561
Item Type: Article (Research - C1)
ISSN: 1476-1645
Date Deposited: 29 Aug 2016 22:04
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320702 Medical infection agents (incl. prions) @ 100%
SEO Codes: 92 HEALTH > 9203 Indigenous Health > 920301 Aboriginal and Torres Strait Islander Health - Determinants of Health @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 50%
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