Hoffman, Stephen L., and Doolan, Denise L. (2000) Malaria vaccines-targeting infected hepatocytes. Nature Medicine, 6 (11). pp. 1218-1219.

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Abstract

[Extract] When an individual is bitten by a female Anopheles sp. mosquito and becomes infected with Plasmodium falciparum (Pf), the parasites exist as extracellular, uninucleate sporozoites in the circulation for less than 30 minutes. After this time, they infect hepatocytes and each sporozoite develops into a schizont containing more than 10,000 uninucleate merozoites. The growing parasite causes the hepatocyte to rup- ture, releasing the merozoites into the bloodstream where each one can subsequently invade an erythrocyte. This initiates a cycle of intra-erythrocytic stage development, rupture, and re-invasion, leading to a 10-20 fold increase in the numbers of parasites in the bloodstream every 48 hours. These asexual erythrocytic-stage parasites are responsible for the clinical manifestations and pathology of the disease we call malaria.

Item ID:	42769
Item Type:	Article (Short Note)
ISSN:	1546-170X
Date Deposited:	17 Mar 2016 02:46
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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