A novel bioceramic scaffold integrating silk fibroin in calcium polyphosphate for bone tissue-engineering

Xie, Huixu, Gu, Zhipeng, Li, Chuansong, Franco, Christopher, Wang, Jianyun, Li, Longjiang, Meredith, Neil, Ye, Qingsong, and Wan, Changxiu (2016) A novel bioceramic scaffold integrating silk fibroin in calcium polyphosphate for bone tissue-engineering. Ceramics International, 42 (2 Part A). pp. 2386-2392.

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Abstract

The advantages of bioceramics, such as biocompatibility and osteoconduction, have been widely used for bone repair and substitute as bone tissue-engineering materials. Bioceramic scaffolds however still need improvement to meet the requirements for complex bone repair. The aim of this study was to develop novel bioscaffolds for bone regeneration, based on the combination of silk fibroin (SF) and calcium polyphosphate (CPP) composite scaffolds. In this study, Bombyx mori silk fibroin (BMSF) and Antheraea pernyi silk fibroin (APSF) were prepared, and applied into CPP scaffolds with glutaraldehyde crosslinking to form the BMSF/CPP and APSF/CPP bioceramics. These scaffolds were then undergone the strength tests, morphology evaluation, and assessments for biodegradation and biocompatibility. Our results showed that the CPP-type biocemmics presented a higher compressive strength and enhanced degradation after the silk fibroin was doped into a CPP structure. Moreover, the BMSF/CPP and APSF/CPP-type scaffolds exhibited lower cellular toxicity than those of the CPP and HA types. Considering the improved mechanical characteristics and degradation as well as ready availability, SF/CPP may be considered a suitable bioceramic for bone tissue-engineering.

Item ID: 42464
Item Type: Article (Research - C1)
ISSN: 1873-3956
Keywords: silk fibroin, scaffold, bone tissue-engineering, calcium polyphosphate
Date Deposited: 03 Feb 2016 14:36
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1116 Medical Physiology > 111699 Medical Physiology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis) @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920118 Surgical Methods and Procedures @ 50%
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