Immune and inflammatory responses of Australian firefighters after repeated exposures to the heat

Walker, Anthony, Keene, Toby, Argus, Christos, Driller, Matthew, Guy, Joshua H., and Rattray, Ben (2015) Immune and inflammatory responses of Australian firefighters after repeated exposures to the heat. Ergonomics, 58 (12). pp. 2032-2039.

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When firefighters work in hot conditions, altered immune and inflammatory responses may increase the risk of a cardiac event. The present study aimed to establish the time course of such responses. Forty-two urban firefighters completed a repeat work protocol in a heat chamber (1005 degrees C). Changes to leukocytes, platelets, TNF, IL-6, IL-10, LPS and CRP were evaluated immediately post-work and also after 1 and 24h of rest. Increases in core temperatures were associated with significant increases in leukocytes, platelets and TNF directly following work. Further, platelets continued to increase at 1h (+31.2 +/- 31.3x10(9)l, p<0.01) and remained elevated at 24h (+15.9 +/- 19.6x10(9)l, p<0.01). Sustained increases in leukocytes and platelets may increase the risk of cardiac events in firefighters when performing repeat work tasks in the heat. This is particularly relevant during multi-day deployments following natural disasters.

Item ID: 42456
Item Type: Article (Research - C1)
ISSN: 1366-5847
Keywords: occupational stress, inflammation, immune response, safety, cardiac risk
Funders: Australian Capital Fire and Rescue Service, United Firefighters Union of Australia, ACT
Date Deposited: 03 Feb 2016 14:44
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1106 Human Movement and Sports Science > 110602 Exercise Physiology @ 60%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 40%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 100%
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