Neurocysticercosis-related mortality in Brazil, 2000-2011: epidemiology of a neglected neurologic cause of death

Martins-melo, Francisco, Ramos, Alberto Novaes Jr, Cavalcanti, Marta Guimarães, Alencar, Carlos Henrique, and Heukelbach, Jorg (2016) Neurocysticercosis-related mortality in Brazil, 2000-2011: epidemiology of a neglected neurologic cause of death. Acta Tropica, 153. pp. 128-136.

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Abstract

Neurocysticercosis (NCC) is an important cause of severe neurological disease mainly in low- and middle-income countries, but data on NCC mortality from endemic areas are scarce. Here we analysed the epidemiological patterns of NCC-related mortality in Brazil. We included all deaths recorded in Brazil between 2000 and 2011, in which NCC was mentioned on death certificates, either as underlying or as associated cause of death. NCC was identified in 1829/12,491,280 deaths (0.015%), 1130 (61.8%) as underlying cause, and 699 (38.2%) as associated cause. Overall age-adjusted mortality rate for the period was 0.97 deaths/1,000,000 inhabitants (95% confidence interval [CI]: 0.83-1.12). The highest NCC-related mortality rates were found in males, elderly, white race/colour and residents in endemic states/regions. Age-adjusted mortality rates at national level decreased significantly over time (annual percent change [APC]: -4.7; 95% CI: -6.0 to -3.3), with a decrease in the Southeast, South and Central-West regions, and a non-significant increasing trend in the North and Northeast regions. We identified spatial and spatiotemporal high-risk mortality clusters located mainly in NCC-endemic areas. Conditions related to the nervous system were the most commonly associated causes of death when NCC was mentioned as an underlying cause, and HIV/AIDS was the main underlying cause when NCC was an associated cause. NCC is a neglected and preventable cause of severe neurologic disease and death with high public health impact in Brazil. There is a clear need to strengthen nationwide epidemiological surveillance and control for the taeniasis/cysticercosis complex.

Item ID: 42411
Item Type: Article (Research - C1)
ISSN: 1873-6254
Keywords: Neurocysticercosis, T. solium, mortality, epidemiology, time trend analysis, spatial analysis, Brazil
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This article was reprinted as: Martins-Melo, Francisco Rogerlandio, Ramos, Alberto Novaes, Cavalcanti, Marta Guimaraes, Alencar, Carlos Henrique, and Heukelbach, Jorg (2017) Reprint of "Neurocysticercosis-related mortality in Brazil, 2000-2011: Epidemiology of a neglected neurologic cause of death". Acta Tropica, 165. pp. 170-178. The reprint version is available at the related URL.

Funders: CAPES
Date Deposited: 03 Feb 2016 14:45
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110904 Neurology and Neuromuscular Diseases @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 70%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 100%
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