Antidepressants for anorexia nervosa

Claudino, Angelica M., de Lima, Mauricio Silva, Hay, Phillipa P.J., Bacaltchuk, Josué, Schmidt, Ulrike U.S., and Treasure, Janet (2006) Antidepressants for anorexia nervosa. Cochrane Database of Systematic Reviews, 2006 (1). CD004365. pp. 1-34.

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Abstract

The aim of the present review was to evaluate the evidence from randomised controlled trials for the efficacy and acceptability of antidepressant treatment in acute AN. Seven small studies were identified; four placebo-controlled trials did not find evidence of efficacy of antidepressants in improving weight gain, eating disorder or associated symptoms, as well as differences in completion rates. Meta-analysis of data was not possible for most outcomes. However, major methodological limitations of these studies (e.g. insufficient power to detect differences) prevent from drawing definite conclusions or recommendations for antidepressant use in acute AN. Further studies testing safer antidepressants in larger and well designed trials are needed to guide clinical practice.

Item ID: 4225
Item Type: Article (Research - C1)
ISSN: 1469-493X
Keywords: anorexia nervosa; antidepressant
Date Deposited: 18 Sep 2009 04:45
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110319 Psychiatry (incl Psychotherapy) @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
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