Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs

Ferreira, Jacques P., Dzikit, T. Brighton, Zeiler, Gareth E., Buck, Roxanne, Nevill, Bruce, Gummow, Bruce, and Bester, Lynette (2015) Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs. Journal of the South African Veterinary Association, 86 (1). pp. 1-7.

[img]
Preview
PDF (Published Version) - Published Version
Available under License Creative Commons Attribution.

Download (336kB) | Preview
View at Publisher Website: http://dx.doi.org/10.4102/jsava.v86i1.12...
 
1
13


Abstract

Induction of anaesthesia occasionally has been associated with undesirable behaviour in dogs. High quality of induction of anaesthesia with propofol has been well described while in contrast variable induction and recovery quality has been associated with diazepam-ketamine. In this study, anaesthetic induction and recovery characteristics of diazepam-ketamine combination with propofol alone were compared in dogs undergoing elective orchidectomy. Thirty-six healthy adult male dogs were used. After habitus scoring (simple descriptive scale [SDS]), the dogs were sedated with morphine and acepromazine. Forty minutes later a premedication score (SDS) was allocated and general anaesthesia was induced using a combination of diazepam-ketamine (Group D/K) or propofol (Group P) and maintained with isoflurane. Scores for the quality of induction, intubation and degree of myoclonus were allocated (SDS). Orchidectomy was performed after which recovery from anaesthesia was scored (SDS) and times to extubation and standing were recorded. Data were analysed using descriptive statistics and Kappa Reliability and Kendall Tau B tests. Both groups were associated with acceptable quality of induction and recovery from anaesthesia. Group P, however, was associated with a poorer quality of induction (p = 0.014), prolonged induction period (p = 0.0018) and more pronounced myoclonus (p = 0.003), but had better quality of recovery (p = 0.000002) and shorter recovery times (p = 0.035) compared with Group D/K. Diazepam-ketamine and propofol are associated with acceptable induction and recovery from anaesthesia. Propofol had inferior anaesthetic induction characteristics, but superior and quicker recovery from anaesthesia compared with diazepam-ketamine.

Item ID: 41928
Item Type: Article (Refereed Research - C1)
Additional Information:

Copyright:© 2015. The Authors. Licensee: AOSIS Open Journals. This work is licensed under the Creative Commons Attribution License.

ISSN: 2224-9435
Funders: University of Pretoria
Date Deposited: 08 Dec 2015 17:51
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070704 Veterinary Epidemiology @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 100%
Downloads: Total: 13
Last 12 Months: 4
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page