Patients with rheumatoid arthritis in the Australian OPAL cohort show significant improvement in disease activity over 5 Years: a multicenter observational study

Littlejohn, Geoffrey, Roberts, Lynden, Bird, Paul, de Jager, Julien, Griffiths, Hedley, Nicholls, Dave, Young, Jennifer, Zochling, Jane, and Tymms, Kathleen E. (2015) Patients with rheumatoid arthritis in the Australian OPAL cohort show significant improvement in disease activity over 5 Years: a multicenter observational study. Journal of Rheumatology, 42 (9). pp. 1603-1609.

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Abstract

Objective: To evaluate disease activity trends in a large cohort of Australian patients with rheumatoid arthritis (RA) from 2009 to 2014.

Methods: This is a multicenter, cross-sectional, noninterventional study of patients with RA treated in Australia. Patients with RA treated at participating OPAL (Optimising Patient outcome in Australian RheumatoLogy) clinics were included in the study. Data, deidentified by patient, clinic, and clinician, were identified using a purpose-written electronic medical record. Patient demographics, disease onset, medications, and disease measures were analyzed. The Disease Activity Score at 28 joints (DAS28) was used to classify patients into the disease activity states of remission: low disease activity, moderate disease activity (MDA), and high disease activity. Choice of therapy was at the discretion of the treating clinician.

Results: At the time of analysis, the database contained 15,679 patients with RA, 8998 of whom fulfilled the inclusion criteria. Mean age was 63.2 years, mean disease duration was 13.8 years, and the majority were women (72.4%). A total of 37,274 individual DAS28-erythrocyte sedimentation rate scores were recorded for the 8998 patients. The frequency of remission increased significantly from 36.7% in 2009 to 53.5% in 2014 (p < 0.001), and that of MDA decreased from 33% (2009) to 22.2% (2014). The use of biologic disease-modifying antirheumatic drugs for the patients in remission increased from 17% in 2009 to 36.9% in 2014.

Conclusion: Contemporary management of RA in Australia shows improvements in disease activity toward the target of remission over a 5-year period.

Item ID: 41892
Item Type: Article (Research - C1)
ISSN: 1499-2752
Keywords: rheumatoid arthritis; disease activity; remission, disease-modifying; antirheumatic drugs
Funders: Roche Products, Australia
Date Deposited: 08 Dec 2015 17:24
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110322 Rheumatology and Arthritis @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis) @ 50%
92 HEALTH > 9202 Health and Support Services > 920204 Evaluation of Health Outcomes @ 50%
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