BDNF, IGF-I, glucose and insulin during continuous and interval exercise in type 1 diabetes

Tonoli, C., Heyman, E., Roelands, B., Buyse, L., Piacentini, F., Berthoin, S., Bailey, S., Pattyn, N., and Meeusen, R. (2015) BDNF, IGF-I, glucose and insulin during continuous and interval exercise in type 1 diabetes. International Journal of Sports Medicine, 36 (12). pp. 955-959.

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Type 1 diabetes (T1D) can have a significant impact on brain function, mostly ascribed to episodes of hypoglycemia and chronic hyperglycemia. Exercise has positive effects on acute and chronic glycemic control in T1D, and has beneficial effects on cognitive function by increasing neurotrophins such as BDNF and IGF-I in non-diabetic humans. The present study examines the effects of different types of exercise intensities on neurotrophins in T1D. 10 participants with type 1 diabetes were evaluated in 3 sessions: high-intensity exercise (10×[60 s 90%Wmax, 60 s 50 W]), continuous exercise (22 min, 70% VO2 max) and a control session. Blood glucose, serum free insulin, serum BDNF and IGF-I were assessed pre/post all the trials and after recovery. Blood glucose significantly decreased after both exercise intensities and BDNF levels increased, with a dose-response effect for exercise intensity on BDNF. IGF-I changed over time, but without a difference between the different exercise protocols. Both exercise intensities change neurotrophins in T1D, but also exhibit a dose response effect for BDNF. The intensity-dependent findings may aid in designing exercise prescriptions for

Item ID: 41877
Item Type: Article (Research - C1)
ISSN: 1439-3964
Keywords: diabetes; physical activity; neurotrophins; cognitive function; cognition
Funders: Vrije Universiteit Brussel (VUB), Research Fund of Flanders (FWO)
Projects and Grants: VUB OZR2096BOF
Date Deposited: 08 Dec 2015 18:43
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1106 Human Movement and Sports Science > 110699 Human Movement and Sports Science not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%
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