Mehrian-Shai, Ruty, Freedman, Shany, Shams, Soheil, Doherty, Joni, Slattery, William, Hsu, Nancy Ya-Hsuan, Reichardt, Juergen K. V., Andalibi, Ali, and Toren, Amos (2015) Schwannomas exhibit distinct size-dependent gene-expression patterns. Future Oncology, 11 (12). pp. 1751-1758.

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Abstract

Aim: Neurofibromatosis type 2 (NF2)-associated vestibular schwannomas have variable size at presentation which presents a unique challenge in NF2 patient management. Therefore, we investigated the molecular signature characteristic of the differences in size for improved individualized precise therapy. Materials & methods: RNA expression analysis was performed on 15 small and 27 large NF2-associated vestibular schwannoma tumors using a microarray analyzing over 47,000 transcripts. Results: A signature of 11 genes was found to be correlated with NF2 tumor size. Conclusion: We have identified the genetic hallmark that differentiates large NF2-associated tumors from smaller tumors. This is the first time that these genes have been shown to be the hallmark for NF2 tumor size.

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